7-Hydroxy Mitragynine (7OHM)

Mitragynine is the primary known active alkaloid in Kratom (Mitragyna speciosa). This plant is common to Thailand and has long been used both for its properties as a stimulant – traditionally used for bolstering mind and body during work - and its opium-like palliative qualities. This plant (and more recently its isolated active components) has a medicinal history; it was used to treat general physical ailments, and has more recently been used to treat drug (opiate) addiction in countries such as New Zealand.

This particular alkaloid present in Kratom is known as 7-Hydroxy-Mitragynine; though constituents such as these are relatively minor in the total composition of the organism, they can have disproportionately potent effects. (This alkaloid is thought to act at a much higher intensity than Mitragynine.) 7-Hydroxy-Mitragynine has been tested and has analgesic effects - those of a painkiller - comparable to morphine. It is supposed that the alkaloid acts on the brain’s nerve endings to inhibit the release of neurotransmitters. However, the compound is structurally different from other opioid agonists; specifically, this composition has had a more potent opioid agonistic effect than has morphine in laboratory tests.

Due to its unique structure and potency, 7-Hydroxy-Mitragynine shows promise in becoming a seed for the development of new analgesics. One of the most significant effects of this extract is that, in comparison with morphine, 7-Hydroxy-Mitragynine is much better absorbed when given orally. Orally administered morphine, it is well documented, is rapidly metabolized in the liver and excreted in urine. This rapid discharge of the drug can lead to increased tolerance and accompanying side effects, because of the increasing amounts of morphine necessary to achieve prior levels of treatment. This can be a significant issue in the clinical use of morphine.

This material is available for the purposes of research and study and we hope to see progress in pain treatment and addiction research.

• 7-Acetoxy-Mitragynine
• Clinical Research Chronic Pain Treatment Compositions
• Kratom (Mitragyna Speciosa)
• Kratom (Mitragyna Speciosa) Pure alkaloid extracts ( Mitragynine 91%hcl)

• Treating Yourself Magazine Interview